Prospective Research Studies of Maturation (PRISM)- Research Project

 描述(由申请人提供)：项目摘要本合作协议(U01)的申请响应NIH RFA-DA-15-015，青少年大脑认知发展(ABCD)研究，成熟度前瞻性研究(PRISM)联盟的5/9研究站点。该联盟的目标是建立一个全国性的、多地点的纵向队列，前瞻性地检查物质使用(SU)从青春期早期到SU和SU障碍的风险期对神经发育和行为的影响。这项对11,000名儿童进行的为期10年的纵向研究将测量大脑发育、SU、认知、情绪、执行功能、心理健康、身体健康、环境，并为未来的遗传学和表观遗传学研究收集生物样本。该联盟有一个优化的研究方案和4个具体目标：1)使用先进的多模式神经成像来评估发病前因素以及与不同SU模式相关的对发育中大脑结构和功能的影响。2)理清不同类型的SU对身体健康、心理社会和认知发展、学业成就、动机和情绪调节的预测作用和结果。3)考察所用物质的数量和组合如何影响精神病理学的表达，反过来，精神病理学的出现又如何影响SU。4)评估所使用的每种物质如何促进其他物质的使用(通道相互作用)。犹他州的网站有三套具体的目标，涉及(1)成像；(2)家庭/遗传学；(3)特殊人群。成像目标：(A)与JHU和UH一起参与MRS/QSM子研究(详情请参阅JHU项目)，以及(B)与宾夕法尼亚大学、加州大学洛杉矶分校和UH一起参与灌注成像子研究(详情请参阅宾夕法尼亚大学项目)。家庭/遗传学目标：(A)将所有犹他州受试者与犹他州人口数据库中的数据交叉登记(犹他州人口数据库：http://healthcare.utah.edu/huntsmancancerinstitute/research/updb/，，该数据库是美国唯一的此类数据库，也是世界上为数不多的此类资源之一)。UPDB的中心组成部分是一套广泛的犹他州家族史，其中家庭成员与人口统计和医疗信息有关，(B)兄弟姐妹超额录取，这是由于犹他州家庭规模大和怀孕间隔相对较短造成的。特殊人口目标：(A)评估独特的青少年人口，即吸食大麻但从未使用过其他药物的人，以及(B)超额招收美洲原住民参与者，他们已知与酒精有关的死亡率要高得多。我们的网站是唯一有资格成为该联盟成员的网站，因为我们在青少年吸毒认知评估和成像研究方面拥有丰富的经验。此外，UPDB在我们的网站上创造了一个前所未有的研究机会。我们认为，我们在这些领域的贡献与其他杰出财团成员的贡献相辅相成，共同实现PRISM财团的总体目标。

 DESCRIPTION (provided by applicant):Project Summary This cooperative agreement (U01) application responds to NIH RFA-DA-15-015, Adolescent Brain Cognitive Development (ABCD) study, 5/9 Research Site of the Prospective Research in Studies of Maturation (PRISM) Consortium. The Consortium's objective is to establish a national, multisite, longitudinal cohort to prospectively examine the neurodevelopmental and behavioral effects of substance use (SU) from early adolescence through the period of risk for SU and SU disorders. This 10-year longitudinal study of 11,000 children will measure brain development, SU, cognition, emotion, executive function, mental health, physical health, environment, and collect biospecimens for future genetics and epigenetic studies. The Consortium has an optimized research protocol and 4 specific aims: 1) Using advanced multi-modal neuroimaging to evaluate premorbid factors and the impact associated with diverse patterns of SU on the structure and function of the developing brain. 2) Disentangle the predictors and consequences of diverse patterns of SU on physical health, psychosocial and cognitive development, academic achievement, motivation and emotional regulation. 3) Examine how the quantity and combination of substances used affect the expression of psychopathology and, conversely, how the emergence of psychopathology influences SU. 4) Assess how each substance used contributes to the use of other substances (gateway interactions). The Utah site has three sets of specific aims involving (1) Imaging; (2) Family/Genetics; and (3) Special Populations. Imaging Aims: (a) participation in the MRS/QSM substudy with JHU and UH (see JHU project for details) and (b) participation in the perfusion imaging substudy along with Penn, UCLA, and UH (see Penn project for details). Family/Genetics Aims: (a) Cross register all Utah subjects with data contained in the Utah Population Database (UPDB: http://healthcare.utah.edu/huntsmancancerinstitute/research/updb/, the UPDB is the only database of its kind in the United States and one of few such resources in the world). The central component of the UPDB is an extensive set of Utah family histories, in which family members are linked to demographic and medical information and (b) over-enroll siblings, which is made possible by the large family size and the relatively short inter-pregnancy interval of Utahns. Special Population Aims: (a) evaluate a unique adolescent population, those who use marijuana but who have never used other drugs and (b) over-enroll Native American participants, who are known to have substantially higher rates of alcohol-related mortality. Our site is uniquely qualified to be part of the Consortium because of our extensive experience with cognitive assessment and imaging studies of drug-using youth. In addition, the UPDB creates an unprecedented research opportunity at our site. We believe that our contributions in these areas complement those of other outstanding consortium members to collectively achieve the overall goals of the PRISM Consortium.