The Effects of Mood on Functional Brain Connectivity in Low Back Pain Patients du

描述（由申请人提供）：本申请的总体目标是进一步了解慢性疼痛的神经机制。最近的研究表明，与健康对照组相比，慢性疼痛患者在静息状态下的默认模式网络（DMN）[5，12，14]功能连接异常，DMN是一组与自由思维相关的大脑区域。这些组间差异被归因于疼痛处理机制，但这一结论存在许多潜在的混淆。参与者通常被指示不要特别思考任何事情，导致不标准的思维过程，从而导致数据解释的模糊性。然而，很少有研究调查参与者的特定行为或认知状态，如情绪或对临床疼痛的关注增加，是否有助于这种非典型的连接。由于消极情绪被假设为增加个体对躯体感觉的注意力[48]，因此在慢性疼痛的经历中，这些神经过程之间可能存在关系。需要更多的研究来检查这些精神状态如何影响慢性疼痛经历中休息状态下的大脑活动[8，9，10]。拟议的工作将试图分解在此范例中某些行为变量和大脑活动之间的关系。本NRSA的具体目的是：1）检查积极和疼痛相关的消极情绪对DMN功能连接的影响; 2）检查静息状态下疼痛相关的注意和情感神经过程之间的时间关系。本研究的发现，希望能提供有用的资讯，以解释慢性疼痛病患的静息状态资料。此外，我们希望解开的时间关系的注意力和情感的过程中的感知临床疼痛，这将有助于通知治疗的发展。

DESCRIPTION (provided by applicant): The overall goal of this application is to further knowledge about the neural mechanisms of chronic pain. Recent studies have shown that patients with chronic pain have abnormal functional connectivity of the default mode network (DMN) [5,12, 14], a group of brain regions associated with freethinking, compared to healthy controls during resting-state. These group differences have been attributed to mechanisms of pain processing, however there are a number of potential confounds to this conclusion. Participants are typically instructed not to think about anything in particular, leading to unstandardized thought processes and, consequently, ambiguity in data interpretation. Few studies, however, have examined whether a participant's specific behavioral or cognitive state, such as mood or increased attention to clinical pain, contributes to this atypical connectivity. Because negative mood has been hypothesized to increase individuals' attention to somatic sensations [48], it is possible that there is a relationship between these neural processes in the experience of chronic pain. More research is needed to examine how these mental states influence brain activity during resting-state in the experience of chronic pain [8, 9, 10]. The proposed work will attempt to decompose the relationship between certain behavioral variables and brain activity during this paradigm. The Specific Aims of this NRSA are to 1) examine the effects of positive and pain-related negative mood on functional connectivity of the DMN and 2) examine the temporal relationship between pain-related attentional and affective neural processes during resting-state. With the findings from this research, we hope to provide useful information to the interpretation of resting-state data in chronic pain patients. Additionally, we hope to disentangle the temporal relationship of attentional and affective processes in the perception of clinical pain, which will help inform treatment development.