Chemical and Structural Biology Program (CSB)

项目001 -项目概要/摘要-化学与结构生物学（CSB） 赵氏综合癌症中心化学与结构生物学课程 （CFCCC）旨在将加州大学欧文分校在合成化学，结构生物学，分析 化学和相关领域对抗癌研究的影响。这些科学领域往往被视为 实验室的努力。因此，CSB计划的主要目标是建立合作和桥梁 研究人员、癌症生物学家和临床医生之间的联系。除了传统的方法， 发展合作（例如，专题务虚会和研讨会），公务员事务局领导层举办了一个非常成功的 分子配对服务，汇集了合成化学家，结构生物学家和生物学家， 有趣的小分子。婚介服务的显著成功包括一类新的抗营养素 在体外和动物模型中具有令人兴奋的抗癌活性的转运蛋白化合物。 通过其活动，CFCCC直接促进了抗癌研究的成功， CSB成员。例如，神经元型一氧化氮合酶成为黑色素瘤的靶点， CFCCC建立的联系很快导致了高度特异性nNOS抑制剂的实验。同样地， 分析化学领域的成功将生物识别与电子学联系起来， 与前列腺癌和膀胱癌医生一起指导临床试验。CFCCC还 提供试点项目资金，帮助启动合成化学家和生物学家之间的研究， 新型抗乳腺癌化合物。公务员事务局的领导层还帮助扩大其 成员进入癌症相关领域;例如，研究人员与一个有前途的新的实验技术， 用蛋白质组学MS绘制蛋白质-蛋白质相互作用图谱，介绍给不同的潜在合作者 为研究打开了新的大门和途径。因此，CSB计划利用现有的努力和优势 扩大在加州大学欧文分校进行的抗癌研究的数量和质量。 成员：来自8个部门的22名成员 资金：459，979美元NCI（总计）; 4，141，394美元其他同行评审（总计） 出版物：158份出版物，16%方案间; 6%方案内

Project 001 - Project Summary/Abstract - Chemical & Structural Biology (CSB) The Chemical and Structural Biology (CSB) Program of the Chao Family Comprehensive Cancer Center (CFCCC) seeks to bring UC Irvine's considerable strengths in synthetic chemistry, structural biology, analytical chemistry and related areas to bear on anti-cancer research. These science areas tend to be pursued as single laboratory efforts. Thus, a major thrust of the CSB program is building collaborations and bridges between CSB researchers and cancer biologists and clinicians. In addition to the traditional methods of developing collaborations (e.g., topical retreats and symposia), the CSB leadership runs a very successful molecular matchmaking service, bringing together synthetic chemists, structural biologists and biologists with interesting small molecules. Notable successes of the matchmaking service include a new class of anti-nutrient transporter compounds with exciting anti-cancer activities in vitro and in animal models. Through its activities, the CFCCC directly contributes to the success of the anti-cancer research pursued by CSB members. For example, neuronal nitric oxide synthase emerged as a target for melanoma, and connections forged by the CFCCC led quickly to experiments with highly specific nNOS inhibitors. Similarly, success in the area of analytical chemistry connecting biological recognition with electronics led to connections with prostate and bladder cancer physicians to guide experiments leading to a clinical trial. The CFCCC also provides pilot project funding, which help initiate studies between a synthetic chemist and biologist leading to new types of anti-breast cancer compounds. The CSB leadership also helps to expand the research of its members into cancer-related areas; for example, researchers with a promising new experimental technique for mapping protein-protein interactions with proteomics MS were introduced to different potential collaborators opening new doors and avenues of research. Thus, the CSB program leverages existing efforts and strengths to amplify the quantity and quality of anti-cancer research taking place at UC Irvine. Membership: 22 Members from 8 Departments Funding: $459,979 NCI (Totals); $4,141,394 Other Peer-Reviewed (Totals) Publications: 158 Publications, 16% Inter-programmatic; 6% Intra-programmatic