Diet and metabolic risks: joint drivers of global epidemiologic transition and he

描述(由申请人提供)：背景-饮食及其对代谢风险因素的影响是全球流行病学转变的关键驱动因素。然而，很少有研究定量评估饮食和代谢危险因素之间的复杂相互关系，它们对心血管疾病(CVD)和糖尿病的综合影响，它们与宏观社会经济变量的关系，以及它们在流行病学转变背景下对全球健康差距的影响。科学目标-1)在整体饮食的背景下研究个人饮食和代谢危险因素之间的相互关系，2)开发 为了量化饮食和代谢风险对心血管疾病和糖尿病的综合影响，采用了先进和可靠的分析方法；3)研究饮食和代谢风险因素如何受到城市化、收入不平等和教育等宏观社会经济因素的影响；4)评估饮食和代谢风险因素及其与宏观社会经济因素的关系如何导致全球健康差距。科学和公共卫生影响--这项工作将在全球流行病学转变的背景下，对饮食、代谢风险和健康的宏观社会经济决定因素之间的关系及其对心血管疾病和糖尿病的综合影响提供关键见解。此外，这项研究将 提供基本的新知识，说明风险因素水平的差异如何影响按性别、种族和年龄划分的全球心血管疾病/糖尿病死亡率差异。这项研究将直接为数据驱动的、有针对性的卫生政策和干预措施提供信息，以遏制不断上升的心血管疾病和糖尿病的流行，并将开发新的跨学科计算方法，以评估多种风险因素对健康的影响。职业目标-我的主要职业目标是成为终身教职的独立研究员，从事严谨的实证工作，专注于了解全球心血管疾病流行的驱动因素，并制定在全球范围内预防心血管疾病和糖尿病的策略。职业影响-该奖项的K99阶段将允许我在有指导的环境中将重点时间花在职业发展活动上，以学习特定的技能，如拨款撰写、公开演讲、发展合作者网络，以及管理研究小组，这些技能是成为独立调查员不可或缺的。此外，它将使我有机会参加高级课程，并从我的导师和资深同事那里学习营养、心血管、社会流行病学和生物统计学方面的高级研究方法和实质性知识。这次培训将使我能够拓宽和深化我的研究范围，特别是因为我的博士学位是在一个不同的领域。该奖项的R00阶段将开启我作为一名独立科学家的职业生涯，在一所研究型大学担任终身教职，使我能够用高质量的分析和出版物建立我的研究计划，同时获得额外的拨款支持。总体而言，K99/R00将对我向独立的科学/专业过渡产生不可估量的影响。

DESCRIPTION (provided by applicant): Background - Diet and its effects on metabolic risk factors are key drivers of the global epidemiologic transition. However, few studies have quantitatively assessed the complex interrelationships between dietary and metabolic risk factors, their combined effects on cardiovascular disease (CVD) and diabetes, their associations with macro-socioeconomic variables, and their influence on global health disparities in the context of the epidemiologic transition. Scientific Objectives- 1) To study the inter- relationship between individual dietary and metabolic risk factors in the context of overall diet, 2) To develop sophisticated and robust analytical methods for quantifying the combined effects of diet and metabolic risks on CVD and diabetes, 3) To examine how dietary and metabolic risk factors are influenced by macro- socioeconomic factors such as urbanization, income inequality, and education, and 4) to evaluate how diet, metabolic risk factors, and their relationship to macro-socioeconomic factors contribute to health disparities globally. Scientific and Public Health Impact - This work will provide key insights into the relationships between diet, metabolic risk, and macro-socioeconomic determinants of health and their combined impacts on CVD and diabetes within the context of the global epidemiologic transition. In addition, this research will provide essential new knowledge on how differences in risk factor levels affect global disparities in CVD/diabetes mortality by gender, ethnicity, and age. This research will directly inform data-driven, targeted health policies and interventions to stem the rising epidemic of CVD and diabetes, and will develop new interdisciplinary computational methodologies for assessing the health effects of multiple risk factors. Career Objectives - My primary career objective is to become an independent researcher in a tenure-track faculty position conducting rigorous empirical work focused on understanding the drivers of the global CVD epidemic and developing strategies to prevent CVD and diabetes worldwide. Career Impact - The K99 phase of this award will allow me to spend focused time on professional development activities in a mentored environment to learn particular skills, such as grant writing, public speaking, developing networks of collaborators, and managing a research group that are indispensible in becoming an independent investigator. In addition, it will allow me the opportunity to take advanced courses and learn high-level research methods and substantive knowledge in nutritional, cardiovascular, and social epidemiology and biostatistics from my mentor and senior colleagues. This training will allow me to broaden and deepen the scope of my research, especially since my doctoral degree was in a different field. The R00 phase of this award will launch my career as an independent scientist in a tenure-track position in a research-oriented university, allowing me to establish my research program with high-quality analyses and publications, while securing additional grant support. Overall, the K99/R00 will have an invaluable impact on my scientific/professional transition to independence.