FOOD-BASED BIOMARKERS, DIET QUALITY, AND CARDIOMETABOLIC HEALTH

基于食物的生物标志物、饮食质量和心脏代谢健康

• 批准号: 9913534
• 负责人: Qi Sun
• 金额: $ 47.87万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913534
• 关键词: Behavior Therapy; Berry; Bioinformatics; Biological Markers; Blood Pressure; Blueberries; Body Weight; C-reactive protein; Calibration; Caring; Chemicals; Chickens; Chronic Disease; Citrus Fruit; Coronary heart disease; Cost Sharing; Data; Databases; Developed Countries; Development; Diabetes Mellitus; Diet; Diet Records; Dietary Assessment; Dietary Intervention; Dietary Questionnaires; Disease; Dose; Eating; Education; Epidemic; Epidemiology; Fabaceae; Food; Foundations; Funding; Funding Agency; Funding Mechanisms; Glycosylated hemoglobin A; Health; Healthy Eating; Hispanic Community Health Study/Study of Latinos; Hispanics; Hour; Human; Incidence; Individual; Intake; International; Intervention Studies; Ireland; Knowledge; Lead; Letters; Lettuce - dietary; Life Style; Link; Measurement; Measures; Meat; Metabolic; Methodology; Molecular Profiling; Northern Ireland; Nurses' Health Study; Nutrient; Nutritional; Nutritional Study; Obesity; Outcome; Participant; Patient Self-Report; Performance; Persons; Population Heterogeneity; Prevalence; Public Health; Qi; Randomized; Recommendation; Relative Risks; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Estimate; Risk Marker; Sampling; Science; Series; Spinach - dietary; Statistical Methods; Strawberries; Study of Latinos; Techniques; Testing; The Sun; United States National Institutes of Health; Urine; Variant; Vegetables; Woman; base; bean; biomarker discovery; biomarker validation; blood lipid; cardiometabolic risk; cardiometabolism; case control; cohort; design; dietary guidelines; disorder risk; epidemiology study; ethnic diversity; feeding; gut microbiota; heart disease risk; high risk; improved; indexing; innovation; men; metabolomics; molecular marker; mortality; novel; novel marker; nutrition; nutritional epidemiology; preference; primary outcome; programs; prospective; randomized trial; research and development; response; secondary outcome; social; sugar; sweetened beverage; urinary; validation studies

Accurate assessment of human diet is the cornerstone of nutritional epidemiology. Biomarkers that are sensitive and specific to food intake can provide objective information that improves the characterization of diet. Advances in metabolomic profiling techniques now permit the discovery of novel food biomarkers, although, thus far, only a limited number of robust food biomarkers have been identified. This proposal represents major research efforts to significantly accelerate the advances in the research of nutrition and health by conducting three research projects: 1) food biomarker discovery and validation; 2) examination of food biomarkers in relation to cardiometabolic health, with a focus on coronary heart disease (CHD); and 3) evaluating food biomarker-guided precision nutrition to improve diet quality and cardiometabolic health. These complementary, inter-connected projects will be led by an investigator team consisting of researchers in the US, Ireland, and Northern Ireland with expertise in metabolomics, nutritional biomarker research, nutritional and chronic disease epidemiology, bioinformatics, and dietary intervention studies. The proposed projects will be jointly funded, without overlapping jurisdictions, by the NIH/USDA, Health Research Board and Science Foundation Ireland in the Republic of Ireland, and the Health and Social Care R&D Division in Northern Ireland through the unique US-Ireland R&D Partnership Programme. Dr. Lorraine Brennan, an internationally recognized leader in food biomarker discovery and metabolomics, will lead efforts in identifying novel food biomarkers using urine samples through controlled human feeding studies in Ireland. Dr. Qi Sun and his US team will lead efforts in evaluating the performance of food markers in assessing habitual diet among free-living individuals who are participants of the Nurses' Health Studies (NHS) and Hispanic Community Health Study / Study of Latinos (SOL). In addition, the US investigators will use food markers to construct a diet quality score and subsequently examine this score in relation to CHD risk in the NHS and SOL studies. Dr. Jayne Woodside will design food marker-guided precision nutrition guidance and evaluate the efficacy of the dietary guidance on improving diet quality and cardiometabolic health through a randomized intervention study in Ireland (North and South). This proposal will leverage the interdisciplinary expertise of the Trans-Atlantic team, rich resources of multi-ethnic cohorts in the US, and a unique cost-sharing mechanism by multiple funding agencies. This project will facilitate discoveries of novel food markers, provide further evidence that links food markers with CHD risk in US men and women with diverse ethnic background, and demonstrate the utility of incorporating food markers in designing precision nutrition strategies for improving diet and human health. This study has a great potential to advance dietary assessment methodology and the development of more effective dietary interventions to improve cardiometabolic health.

对人类饮食的准确评估是营养流行病学的基石。对食物摄入量敏感和特异的生物标志物可以提供改善饮食特征的客观信息。代谢组学技术的进步现在使得发现新的食品生物标记物成为可能，尽管到目前为止，只鉴定了数量有限的强大的食品生物标记物。这项建议代表了显著加快营养和健康研究进展的重大研究努力，通过实施三个研究项目：1)食品生物标记物的发现和验证；2)检测与心脏代谢健康有关的食品生物标记物，重点是冠心病(CHD)；以及3)评估食品生物标记物引导的精确营养，以改善饮食质量和心脏代谢健康。这些相互补充、相互关联的项目将由一个研究团队领导，该团队由美国、爱尔兰和北爱尔兰的研究人员组成，他们在代谢组学、营养生物标记物研究、营养和慢性病流行病学、生物信息学和饮食干预研究方面具有专业知识。拟议的项目将由爱尔兰共和国的NIH/USDA、健康研究委员会和爱尔兰科学基金会以及北爱尔兰的健康和社会护理研发部门通过独特的美国-爱尔兰研发伙伴计划共同资助，而不存在管辖权重叠。Lorraine Brennan博士是国际公认的食品生物标记物发现和代谢组学方面的领导者，他将在爱尔兰通过受控人类喂养研究，领导使用尿样识别新的食品生物标记物的努力。孙琦博士和他的美国团队将领导评估食品标记物在评估自由生活个体中的习惯性饮食方面的表现，这些个体是护士健康研究(NHS)和拉美裔社区健康研究/拉美裔研究(SOL)的参与者。此外，美国调查人员将使用食品标记物来构建饮食质量评分，并随后在NHS和SOL研究中检查该评分与CHD风险的关系。Jayne Woodside博士将设计食品标记物引导的精确营养指南，并通过在爱尔兰(北部和南部)进行的随机干预研究来评估饮食指南在改善饮食质量和心脏代谢健康方面的有效性。这项提议将利用跨大西洋团队的跨学科专业知识、美国多种族群体的丰富资源，以及多个资助机构的独特成本分担机制。该项目将促进新的食品标记的发现，提供进一步的证据，将食品标记与不同种族背景的美国男性和女性的CHD风险联系起来，并展示将食品标记纳入设计改善饮食和人类健康的精确营养战略的效用。这项研究对改进饮食评估方法和开发更有效的饮食干预措施以改善心脏代谢健康具有巨大的潜力。