NanoSystems Biology Cancer Center Nano/micro Fabrication and Materials (NM2) Core

共享资源核心。 纳米系统生物学癌症中心纳米/微制造与材料(NM2)核心 摘要： 纳米/微米制造和材料(NM2)核心是NSBCC定制设计的核心资源。通过 提炼出个别项目特定目标的研究需求，我们确定了一套研究工具 4个项目中至少有3个项目需要这些资源，或者至少有2个项目大量使用这些资源。这些 工具归结为(1)基于微芯片的平台的微纳制造和执行的资源 相关分析的资源；(2)纳米颗粒表征的资源；以及(3)肽和 生物分子的制备、修饰和提纯。我们将这些常见的研究需求视为 有机会提高我们项目的成本效益，同时通过促进交叉来加快进度 在项目之间培养思想、知识和研究人员。在核心总监的指导下 吉姆·希思博士(加州理工学院)和联席主任杨锡申博士(加州大学洛杉矶分校)这些研究需要，以及由此产生的 教育和科学机会，通报中央的组成和行政结构 托管的NM2核心，在加州理工学院和加州大学洛杉矶分校都有办事处。

Shared Resources Cores. NanoSystems Biology Cancer Center Nano/micro Fabrication and Materials (NM2) Core ABSTRACT: The Nano/micro fabrication and Materials (NM2) Core is a custom-designed Core Resource of the NSBCC. By distilling out the research needs of the individual Project Specific Aims, we identified a set of research tools that were needed by least 3 out of the 4 projects, or which were heavily used by at least 2 projects. These tools beak down into (1) resources for micro/nano fabrication of microchip-based platforms and the execution of the associated assays; (2) resources for nanoparticle characterization; and, (3) resources for peptide and biomolecular preparation, modification, and purification. We view these common research needs as an opportunity to increase the cost-efficiency of our Projects, while also accelerating progress by promoting cross- fertilization of ideas, knowledge, and researchers between the projects. Under the direction of Core Director Dr. Jim Heath (Caltech) and co-director Dr. Young Shik Shin (UCLA) these research needs, and the resultant educational and scientific opportunities, inform the composition and administrative structure of a centrally managed NM2 core, with locations at both Caltech and UCLA.