Integrative Pharmacological Sciences Training Program (IPSTP)

项目总结/摘要 该综合药理学科学培训计划（IPSTP）旨在支持第二和第三年 博士从事药理学论文研究项目的学生。受训人员和培训 教师来自7个博士学位。生物化学与分子生物学、化学、化学工程 微生物学和分子遗传学，神经科学，药理学和毒理学， 生理学）。IPSTP中的两个独特重点领域是体内药理学培训 方法和药物发现。IPSTP培训教师的研究专长分为三个集群 重叠的主题：1）疾病的分子机制与新的治疗设计的交叉; 2） 内分泌和代谢紊乱与癌症和心血管过程的整合;以及3） 应用系统生物学和生物信息学来理解药物机制和疾病。资金 要求支持8名学生（或每年4名学生进入该计划）。培训计划将是 由一名项目主任（Neubig），两名副主任（Dorrance和Atchison）和一名 执行委员会由各方案的代表组成。该计划还受到一个 药理学博士专家外部咨询委员会项目和制药行业 以及由受训人员组成的学生咨询委员会。培训计划有8个核心要素： 研究项目，其结果导致博士学位。论文和贡献的知识， 药理学科学; 2）为期两周的药物发现和体内药理学强化课程; 3） 药理学和生物统计学三门课程; 4）专业两门课程 开发; 5）参与定量系统生物学研讨会; 6）每月交流技能 和专业发展论坛; 7）参加年度计划务虚会; 8）每月学生运行 日记俱乐部。学生将被要求参加最后三个元素的时间为他们的直接 T32支持和所有随后的几年，直到毕业。学员还必须参加 负责任的研究行为（RCR）研讨会系列由研究生院和计划提供 具体的RCR活动。学员可参加的补充活动包括：1）教学机会; 2） 参与NIH资助的MSU BEST计划，以及3）实地考察非学术性的区域站点 careers. IPSTP制定了一项全面的计划，以招收高素质的学生，包括在- 代表少数民族学生。IPSTP将为学员提供优秀的研究和专业知识。 培训，并将准备他们在学术界，工业界和政府的研究生涯。

Project Summary / Abstract This Integrative Pharmacological Sciences Training Program (IPSTP) is designed to support 2nd and 3rd year Ph.D. students pursuing dissertation research projects in the pharmacological sciences. Trainees and training faculty are drawn from 7 Ph.D. programs (Biochemistry & Molecular Biology, Chemistry, Chemical Engineering and Materials Science, Microbiology & Molecular Genetics, Neuroscience, Pharmacology & Toxicology and Physiology). The two areas of unique focus within the IPSTP are training on in vivo pharmacological approaches and drug discovery. The research expertise of IPSTP training faculty is clustered into three overlapping themes: 1) the intersection of molecular mechanisms of disease with novel therapeutic design; 2) integration of endocrine and metabolic derangements with cancer and cardiovascular processes; and, 3) application of systems biology and bioinformatics to understand drug mechanisms and disease. Funds are requested to support 8 students (or 4 students entering the program per year). The training program will be administered by a Program Director (Neubig), two Associate Directors (Dorrance and Atchison) and an Executive Committee composed of representatives from the programs. The program is also guided by an External Advisory Committee of experts from Pharmacology Ph.D. programs and the pharmaceutical industry and a Student Advisory Committee composed of trainees. There are 8 core elements to the training plan: 1) a research project whose results lead to a Ph.D. dissertation and a contribution to knowledge in the pharmacological sciences; 2) two week-long intensive courses in drug discovery and in vivo pharmacology; 3) a three course curriculum in pharmacology and biostatistics; 4) a two course curriculum in professional development; 5) participation in a quantitative systems biology workshop; 6) a monthly Communications Skills and Professional Development Forum; 7) participation in an annual program retreat; 8) a monthly student-run journal club. Students will be expected to participate in the last three elements for the duration of their direct T32 support and for all subsequent years until graduation. Trainees are also required to attend the Responsible Conduct of Research (RCR) workshop series provided by the Graduate School and program specific RCR activities. Supplemental activities available to trainees include: 1) teaching opportunities; 2) participation in the NIH-funded MSU BEST program, and 3) field-trips to regional sites for non-academic careers. The IPSTP has developed a comprehensive plan to recruit highly qualified students including under- represented minority students. The IPSTP will provide trainees with excellent research and professional training and will prepare them for research careers in academia, industry and government.