Clinical, Laboratory, and Data Management Core

项目概述（见说明）：临床、实验室和数据管理核心（Core B）建立基础设施来收集、存储和传播临床和实验室数据以及来自项目1、2和3中提出的科学目标的受试者的标本。它位于西北大学（NU），是招募具有明确特征的CRS三级护理患者的主要地点。核心B将监督数据和样本的一致性，并作为拟议的跨机构项目的纽带。实现这些目标。核心B将提高北大CRS患者临床特征的分辨率，并提供一种追踪纵向结果的机制，以增强项目2和项目3研究结果的临床影响。为确保项目1和项目2样本采集的一致性，核心将对相关人员进行培训，并提供样本采集协议共享平台。Core B还提供了一个资源，用于先导和优化生成P2和P3微生物刺激标本的方案。最后，它为所有三个项目提供符合hlpaa的临床数据收集、标本跟踪和数据分发的信息技术基础设施。核心主任Robert Kern，医学博士，是NU耳鼻喉科的主席，具有丰富的管理和临床经验。其他关键人员包括Atsushi Kato博士（Co-I），他是核心实验室部分的负责人。Kato博士在免疫学研究，特别是CRS研究方面拥有丰富的经验。Bruce Tan，医学博士（Co-I）是一名具有鼻窦疾病临床专业知识和分子和细胞生物学实验室经验的内科科学家。Tan博士目前是K23基金获得者，对CRS流行病学和数据管理以及应用于临床研究的信息技术有兴趣和经验。此外，核心B通过沃伦·基布博士领导的生物信息学中心（NUBIC）利用NU提供的机构专业知识；Alfred Rademaker博士领导的生物统计学合作中心（BCC）；以及Frank Schleicher领导的Feinberg医学院（FSM）信息系统理事会。

PROJECT SUMMARY (See instructions): The Clinical, Laboratory and Data Management Core (Core B) establishes infrastructure to collect, store and disseminate clinical and laboratory data as well as specimens from subjects in support ofthe scientific aims proposed in Projects 1, 2 and 3. It is physically located and coordinated at Northwestern University (NU) and serves as a primary site for the recruitment of well-characterized tertiary-care patients with CRS. Core B will provide oversight of data and specimen consistency and serve as the nexus for the trans-institutional projects proposed. To achieve these aims. Core B will increase the resolution of clinical characterization of CRS patients at NU and provide a mechanism for tracking longitudinal outcomes to enhance the clinical impact of findings in Project 2 and Project 3. To ensure consistency of sample acquisition in Project 1 and Project 2, the core will conduct training for relevant personnel and provide a platform for sharing of protocols for sample acquisition. Core B also provides a resource that pilots and optimizes protocols for generating microbial-stimulated specimens for P2 and P3. Finally, it provides the information technology infrastructure for HlPAA-compliant clinical data collection, specimen tracking and data dissemination for all three projects. The Core Director, Robert Kern, MD, is the Chairman of Otolaryngology at NU, with extensive administrative and clinical experience. Other key personnel include Atsushi Kato, PhD (Co-I), who is the leader ofthe laboratory portion ofthe core. Dr. Kato has extensive experience in immunology research, and CRS research in particular. Bruce Tan, MD (Co-I) is a physician scientist with clinical expertise in sinonasal disorders and laboratory experience in molecular and cell biology. Dr. Tan, a current K23 grant recipient, has interest and experience in the epidemiology of CRS and data management and in information technology as applied to clinical research. Additionally, Core B leverages institutional expertise available at NU through the Bioinformatics Center (NUBIC) under Warren Kibbe, PhD; the biostatistics collaboration center (BCC) under Alfred Rademaker, PhD; and the Feinberg School of Medicine (FSM) information systems directorate under Frank Schleicher.