NINDS Stroke Trials Network - Regional Coordinating Center

描述（由申请人提供）：中风是一种常见的神经系统疾病，是一个日益严重的公共卫生问题。虽然死亡率正在下降，但它仍然是美国第四大死亡原因，它仍然是残疾的主要原因，并且预计随着人口老龄化，受影响的个体数量将显著增长。NINDS的使命是减轻神经系统疾病的负担，如中风。NINDS资助的中风试验往往遭受长启动时间和延迟完成研究。需要一种更好的方法来进行更大规模的中风临床研究。本申请的主要目标是成为NINDS卒中试验网络中的区域协调卒中中心（RCC）。该网络的目的是加速和促进中风治疗、预防和康复方面的科学进步的转化。通过网络进行这种研究将提高进行试验的效率和效力。进行中风研究的基础设施将不需要随着每一项新的试验而重新组织。审判将更快地开始和完成。临床和生物学数据的标准化也将有助于未来的工作。这样一个网络将加强合作，并将作为试验设计的孵化器。此外，该网络还将扩大对 急性期、预防期和恢复期的受试者。明尼苏达大学及其中风项目是唯一有资格为区域协调中心服务的。它可以访问与该领域相关的广泛的学术研究人员，在临床研究的各个领域具有深度。它还可以借鉴实施研究网络的经验，作为NINDS神经学紧急研究网络（NETT）的当前成员。该应用程序和该计划的领导者在中风临床研究，通过网络研究方面经验丰富，并且是该主题的专家。为成功实施试验而进行合作所需的各种专业已经在传统部门以外的合作单位中进行了行政调整。总的来说，明尼苏达大学目前的中风项目是领导RCC的绝佳候选人。

DESCRIPTION (provided by applicant): Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number 4 cause of death in the U.S. It is still a major cause of disability, and is expected to significantl grow in number of affected individuals with aging of the population. The mission of NINDS is to reduce the burden of neurological disease, such as stroke. NINDS funded stroke trials have often suffered from long start up time and delays in completing the research. A better way of conducting stroke clinical research on a larger scale is needed. The main objective of this application is to be a Regional Coordinating Stroke Center (RCC) in the NINDS Stroke Trials Network. The purpose of the network is to accelerate and facilitate translation of scientific advancement in stroke treatment, prevention and recovery. Performing such research through the network will introduce a higher degree of efficiency and effectiveness in conducting the trials. The infrastructure to conduct stroke research will not need to be reorganized with every new trial. Trials will be initiated and completed faster. Standardization of clinical and biologica data will also be useful for future work. Enhanced collaboration will result from such a network, and will function as an incubator for trial design. In addition, the network will broaden access to subjects in the acute phase, prevention, and recovery periods. The University of Minnesota and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It can also draw on the experience of implementing research network, as a current member in the NINDS Neurological Emergency Research Network (NETT). The leaders for this application and of the program are experienced in stroke clinical research, research through networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Overall, the current stroke program at the University of Minnesota is an excellent candidate for leading an RCC.