Network on Measurement of Biological Risk

项目摘要/摘要 该项目的目标将是进一步发展和维持一个跨学科的科学家网络。 致力于在具有代表性的老龄化大样本中衡量晚年健康结果的生物风险 人口。生物风险是由遗传和生理状态的指标来定义的，这些指标会增加 疾病、残疾、身体或认知功能丧失或死亡的可能性。该网络将专注于 评估、验证和协调人口研究中的生物风险测量；扩大 可在人群中使用的措施；以及制定包括复杂结构的方法 分析模型中的健康维度。 该项目将在建立初步的跨学科研究网络的基础上取得广泛进展。 (2009年至2015年由NIA提供资金)。该网络2016-2021年期间的活动将包括设计 并举行一系列一般性和重点会议，包括一次网络年度会议 成员、与工作组的定期会议/电话会议、专门讲习班、与 开展个别研究，制定数据收集和处理计划，并支持小型试点项目，以 协调和发展测量。将传播统一的信息和统一的数据 该网络的主要产品。该网络还将传播收集方法、分析方法的协议 方法、质量控制方法、协调方法、有关样品主题的基础培训 收集和制备，以及分析方法。 该网络将促进有效的跨学科和国际研究， 生物、经济和心理因素以及导致健康结果的生物途径 大型社区和全国人口调查中的老龄问题。这一日益增长的科学关注领域在 人口科学正处于从有组织的网络中进一步发展的关键阶段。

Project Summary/Abstract The goal of this project will be to further develop and maintain an interdisciplinary network of scientists dedicated to measuring biological risk for late life health outcomes in large representative samples of aging populations. Biological risk is defined by indictors of genetic and physiological state that increase the probability of disease, disability, loss of physical or cognitive functioning, or death. The network will focus on assessing, validating, and harmonizing biological risk measurement in studies of populations; expanding measures available for use in populations; and developing methodological approaches for including complex dimensions of health in analytic models. This project will build on the extensive progress made building an initial interdisciplinary research network (funded by NIA from 2009 to 2015). Activities of the network for the 2016-2021 period will include designing and carrying out a series of general and focused meetings including one annual meeting of the network members, regular meetings/conference calls with working subgroups, specialized workshops, working with individual studies to develop plans for data collection and processing, and supporting small pilot projects to harmonize and develop measurement. Dissemination of harmonizing information and harmonized data will be a major product of the network. The network will also disseminate protocols for collection methods, assay methods, quality control methods, harmonization methods, basic training on relevant topics of sample collection and preparation, and analytic methods. The network will promote valid interdisciplinary and international research on the associations of social, biological, economic, and psychological factors and the biological paths leading to health outcomes common in old age in large community and national population surveys. This growing area of scientific focus in the population sciences is at a crucial stage for further development from an organized network.