Pharmacogenetics of Tissue Androgen Activation

这项研究旨在确定男性之间自然发生的基因变异，这些变异改变了主要男性荷尔蒙睾丸素对男性健康和医疗保健的影响。这项研究将考察新的因素，这些因素决定了任何特定的男性可能从睾酮暴露中获得多少好处，例如在肌肉和骨骼发育方面，以及在心血管和前列腺疾病方面遭受有害影响。这可能会澄清男性健康如何确定的一些新方面，以及为男性开发新的定制医疗方法。

This study aims to identify naturally occurring genetic variations between men which modify the impact of testosterone, the major male hormone, on men's health and medical care. This study will examine new factors which determine how much any particular man may gain benefit from testosterone exposure such as in muscle and bone development as well as suffer detrimental effects on cardiovascular and prostate diseases. This may clarify some new aspects of how men's health is determined as well as developing new, customized medical treatments for men.