Polyunsaturated fatty acids mimetics with anti-inflammatory properties

自身免疫性疾病是造成我们社区高发病率和高死亡率的原因。免疫抑制药物和抗炎药物在治疗这些疾病以及帮助防止移植组织器官的排斥反应方面发挥了重要作用。医学界正在为这些目的寻找更好的免疫抑制药物和制剂。基于过去几年的研究，我们已经部分确定了多不饱和脂肪酸（PUFA）的结构元件，这些元件负责特定的生物学功能。利用这些信息，我们已经合成了大量以前无法获得的PUFA，我们可以用它来靶向T淋巴细胞，并驱动这些化合物的生物活性，优先用于免疫抑制。通过本项目概述的研究，我们可能会发现一种先导免疫抑制化合物，或者为进一步合成pufa基化合物提供新的信息，以进一步研究作为潜在免疫抑制剂的化合物。

Autoimmune diseases are responsible for a high incidence of morbidity and mortality in our community. Immunosuppressive drugs-anti-inflammatory agents have played important roles in treatment of these diseases as well as in helping to prevent rejection of transplanted tissues-organs. There is an ongoing search by the medical community for better immunosuppressive drugs and agents for use for these purposes. Based on studies conducted in the last few years, we have partially identified structural elements on polyunsatrated fatty acids (PUFA) which are responsible for specific biological functions. Using this information, we have synthesized a large panel of previously unavailable PUFA which we can use to target T lymphocytes and drive the biological activity of these compounds, preferentially towards immunosuppression. By conducting the research outlined in this project, we are likely to either identify a lead immunosuppressive compound or generate new information for further synthesis of PUFA-based compounds for further examination as potential immunosuppressive agents.