Prediction of adverse outcomes following a fragility fracture

已有骨折的患者发生再骨折和过早死亡等不良后果的风险增加，但原因尚不清楚。我们建议评估危险因素和预后模型，以预测不良结果的风险。我们还建议建立一个定量的风险-收益框架来评估这种预后模型的临床效用，并帮助确保治疗方法适当地解决骨质疏松症患者的现实生活经验。

Individuals with an existing fracture are at increased risk of adverse outcomes such as re-fracture and premature mortality, but it is not clear why. We propose to evaluate risk factors, and prognostic models, for predicting the risk of adverse outcomes. We also propose to develop a quantitative risk-benefit framework for evaluating the clinical utility of such prognostic models and help ensure that therapies appropriately address real-life experience of osteoporotic patients.