Preventing Adverse Effects of Matrix Metalloproteinases in Diabetic Wound Healing

糖尿病足溃疡的治疗对糖尿病患者和医疗保健系统来说是一个巨大的挑战。尽管进行了协调一致的治疗，但许多溃疡无法愈合，正是这种未能愈合的问题最终导致了深层次感染和截肢。由于这些原因，开发新的治疗策略来改善糖尿病的伤口愈合是至关重要的。在这项研究中，我们研究了基质金属蛋白酶，特别是基质金属蛋白酶-9在糖尿病创面中的作用，并研究了抑制基质金属蛋白酶是否会改善糖尿病创面的愈合。

Treatment of diabetic foot ulcers presents a significant challenge to diabetic patients and the health care system. Despite concerted treatment, many ulcers do not heal and it is this failure to heal which eventually leads to deep-seated infection and amputation. For these reasons development of new therapeutic strategies to improve wound healing in diabetes is of critical importance. In this study we investigate the role of MMPs in particular MMP-9 in diabetic wounds and examine whether MMP inhibition will improve wound healing in diabetes.