Randomised controlled trials of prophylactic hypothermia to improve outcomes for patients with severe traumatic brain injury, and of optimised patient blood transfusion in critically ill patients.

首先，一项大型多中心试验(POLLE)将补充我之前在创伤性脑损伤(TBI)患者中进行的成功试验，并将确定主动治疗降温是否将实现其改善患者预后的承诺。其次，一项全国性的多中心试验(INTUSE)将确定输血单位的储存时间是否比通常短，是否会改善患者的预后。

First, a large multicentre trial (POLAR) will complement my previous successful trials in traumatic brain injury (TBI) patients and will establish whether active therapeutic cooling, commenced early after brain injury and continued in intensive care units, will achieve its promise of improving patient outcomes. Second, a national multicentre trial (TRANSFUSE) will establish whether transfusing blood units with a shorter than usual storage time will improve patient outcomes.