Randomised controlled trial of intravenous antivenom versus placebo in the treatment of redback spider bite

红背蜘蛛咬伤是澳大利亚最常见的严重环境，而由近亲寡妇蜘蛛咬伤是一个主要的全球问题。尽管红背蜘蛛抗蛇毒血清被广泛使用，但没有对照研究测试过它的有效性。本研究旨在通过一项大型多中心随机对照试验——RAVE-II来测试抗蛇毒血清与安慰剂的疗效。确定一种已知有过敏反应风险的昂贵治疗方法是否有效是至关重要的。

Redback spiderbite is the most common significant envenoming in Australia and bites by the closely related widow spiders are a major global problem. Despite widespread use of redback spider antivenom, no controlled study has tested its effectiveness. This study aims to test the efficacy of antivenom versus placebo in a large multicentre, randomised controlled trial - RAVE-II. It is of critical importance to determine if an expensive treatment with a known risk of allergic reactions is effective.