Reconstructing Transcriptional Networks in Leukaemic Cells

癌症干细胞采用正常干细胞的特性在体内存活和增殖。如果我们要在不根除正常干细胞的情况下根除癌症干细胞，认识和靶向这些细胞之间存在的生物学差异是至关重要的。我们的目标是首先了解“干性”是如何在正常细胞和白血病细胞中维持的，最终目标是拆除后者的“干性”，同时保留前者的“干性”。

Cancer stem cells adopt properties of normal stem cells to survive and proliferate in the body. If we are to eradicate cancer stem cells without eradicating normal stem cells, it is of fundamental importance to recognize and target biological differences that exist between these cells. Our aim is to first understand how ‘stemness’ is maintained in normal and leukaemic cells with the ultimate objective of dismantling ‘stemness’ in the latter whilst preserving it in the former.