Red cell disorders and the regulation of iron homeostasis

铁是一种必需的营养物质，但过量的铁也是有毒的，所以必须严格控制进入身体和周围的铁的量。在这个项目中，我们将研究这种体内铁运动是如何被调节的，特别是巨噬细胞所起的作用，巨噬细胞是清理旧红细胞的细胞。了解这一过程将对分析和治疗重要的血液疾病和铁代谢紊乱有很大的好处。

Iron is an essential nutrient, but it is also toxic when present in excess, so the amount of iron moving into and around the body must be tightly controlled. In this project we will investigate how this body iron movement is regulated, and in particular the role played by macrophages, the cells that clean up old red blood cells. An understanding of this process will be of great benefit in the analysis and treatment of important blood diseases and disorders of iron metabolism.