Redefining antibiotic resistance plasmid transfer in Staphylococcus aureus

耐多药的金黄色葡萄球菌是一个主要的健康问题。抗药性的迅速发展是因为细菌有效地获得/共享抗药性基因。我们的发现表明，DNA转移机制比之前预期的更加多样化和广泛，这对许多病原体具有广泛的影响。该项目旨在确定每种机制的流行率和关键特征，以便可以设计治疗方法来扰乱耐药性的演变和传播。

Multidrug-resistant Golden Staph bacteria are a major health problem. Resistance develops rapidly because bacteria efficiently acquire/share resistance genes. Our discoveries suggest DNA transfer mechanisms are far more diverse and widespread than previously expected and this has wide-reaching implications for numerous pathogenic organisms. This project aims to define the prevalence and key features of each mechanism so treatments can be devised to disrupt the evolution and spread of resistance.