Analysis of killer T cell geometry during an anti-tumour response
Analysis of killer T cell geometry during an anti-tumour response
批准号:
nhmrc : 1032670
负责人:
Dr Paulus Mrass
金额:
$36.49万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
癌症是世界各地的一个主要健康问题。目前使用的癌症治疗方案的缺点是,它们还会损害健康组织。这限制了可以给药的剂量,经常导致治疗失败。抗肿瘤杀伤T细胞是一种自然产生的细胞类型,可以导致肿瘤消退。在目前的提案中,我们探索如何进一步提高这些细胞类型的效率,以诱导对进展中的肿瘤的排斥反应。
英文摘要
Cancer is a major health problem around the world. Currently used treatment options of cancer have the drawback that they also damage healthy tissues. This limits the dosages that can be administered, frequently resulting in treatment failure. Anti-tumour killer T cells are a naturally occurring cell type that can cause tumour regression. In the present proposal, we explore how the efficiency of these cell-types can be further enhanced to induce rejection of progressing tumours.
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会议论文
Real-time analysis of tumour-infiltrating T cells using novel analytical tools
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批准号:DP110104429
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项目类别:Discovery Projects
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资助金额:$23.93万
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财政年份:2011
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负责人:Dr Paulus Mrass
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依托单位:
The impact of granzyme B on cytotoxic T cell migration through tissue
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批准号:nhmrc : 1007830
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项目类别:NHMRC Project Grants
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资助金额:$40.41万
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财政年份:2011
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负责人:Dr Paulus Mrass
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依托单位:
Mechanisms of T cell migration and interactions in tumours
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批准号:nhmrc : 512265
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项目类别:NHMRC Project Grants
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资助金额:$40.63万
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财政年份:2008
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负责人:Dr Paulus Mrass
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依托单位:
海外基金