The distinctive roles of tissue transglutaminase isoforms in neuroblastoma

神经母细胞瘤是儿童早期最常见的实体瘤。由N-Myc癌基因引起的神经母细胞瘤约占该疾病的三分之一，是一种更具侵袭性的亚型，临床结果较差。本项目旨在确定n - myc诱导的神经母细胞瘤发生的相关因子和神经母细胞瘤细胞对抗癌药物的敏感因子，为儿童神经母细胞瘤联合治疗的临床试验提供依据。

Neuroblastoma is the commonest solid tumour in early childhood. Neuroblastoma caused by N-Myc oncogene accounts for about one third of the disease and represents a more aggressive subtype with a worse clinical outcome. This project aims to identify factors responsible for N-Myc-induced neuroblastoma initiation and factors sensitizing neuroblastoma cells to anti-cancer drugs, and to provide the basis for clinical trials of a combination therapy in children with neuroblastoma.