The formation and development of the ovarian follicular membrana granulosa

为了使卵巢能够释放卵子并产生雌激素等激素，卵泡必须在卵巢内生长。每个卵泡包含一个卵子，当卵泡很大并充满液体时，它会破裂，在排卵过程中释放液体和卵子。卵泡结构的一个关键部分是称为基膜的非细胞层。这个基膜包裹着内细胞、卵子和卵泡中的液体。每个女性在出生前都有数百万个卵泡，在她的生育期有数万个，在绝经期没有一个。由于她一生中只排卵约500个，大多数卵泡在发育到排卵大小的过程中死亡。这个项目将研究卵泡壁的结构以及构成该壁的细胞。这些细胞在卵泡生长过程中是如何复制的还从未被发现。这项研究对许多患有多囊卵巢疾病的女性具有重要意义，因为她们的卵泡无法长到完全大小。我们将直接检查这些卵巢。这项研究在试管受精的下一阶段开发中也具有重要意义。

In order for the ovary to be able to release eggs and produce hormones such as oestrogen, follicles must grow within the ovary. Each follicle contains one egg and when the follicle is large and filled with fluid it can rupture, releasing the fluid and egg in the process of ovulation. A key part of the structure of the follicle is a non-cellular layer called the basal lamina. This basal lamina encapsulates the inner cells, the egg and the fluid in the follicle. Each women has millions of follicles prior to her birth, ten of thousands in her reproductive years, and none at the menopause. Since she only ovulates about 500 in her lifetime most follicles die in the process of growing to ovulatory size. This project will examine the structure of the follicle wall and the cells that make up that wall. How these cells replicate during follicle growth has never been discovered. This research has important implications for the many women who have polycystic ovarian disease, whose follicles fail to grow to full size. We will be examining these ovaries directly. The research also has importance in the next phase of IVF developments.