The fungal SEC14 secretory pathway and virulence

侵袭性真菌感染是一个严重的、不断升级的健康问题。它们会导致严重的疾病，死亡率很高，并且对卫生系统来说代价非常高昂。目前的药物往往疗效不佳，并引起副作用。迫切需要新药。许多真菌，包括与艾滋病相关的病原体新生隐球菌，都会分泌磷脂酶B(PlBP)来促进感染。我们将发现并研究PlBP分泌途径作为一种新的抗真菌药物靶点。

Invasive fungal infections are a serious, escalating health issue. They cause severe disease with high death rates and are very costly to the health system. Current drugs often have suboptimal efficacy and cause side effects. New drugs are needed urgently. Many fungi, including the AIDS-related pathogen, Cryptococcus neoformans, secrete phospholipase B (Plbp) to facilitate infection. We will identify and investigate the Plbp secretion pathway as a novel anti-fungal drug target.