The genetic causes of male infertility

6%的澳大利亚男性不育。在这些病例中，50%被认为是遗传起源的。在这个项目中，我们将在小鼠身上复制与人类男性不育相关的高置信度遗传变异。这样做将允许指定明确的基因型-表型相关性，并为临床医生和患者制定高度可信的建议。它还将提供一种手段，以确定未来有利于生育的治疗的行动机制和工具。

6% of Australian men are infertile. Of these cases 50% are thought to be genetic in origin. Within this project we will replicate high-confidence genetic variants associated with human male infertility in the mouse. Doing so will allow the assignment of definitive genotype-phenotype correlations and the formulation of high confidence advice for clinicians and patients. It will also provide a means to define the mechanism of action and the tools for future pro-fertility treatments.