The genetic causes of male infertility

男性不育的遗传原因

• 批准号: nhmrc : 1120356
• 负责人: Prof Moira O'Bryan
• 金额: $ 106.14万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-causes-male-infertility/946510
• 关键词: genetic; causes; male; infertility

6% of Australian men are infertile. Of these cases 50% are thought to be genetic in origin. Within this project we will replicate high-confidence genetic variants associated with human male infertility in the mouse. Doing so will allow the assignment of definitive genotype-phenotype correlations and the formulation of high confidence advice for clinicians and patients. It will also provide a means to define the mechanism of action and the tools for future pro-fertility treatments.

6%的澳大利亚男性不育。这些病例中有50%被认为是遗传性的。在这个项目中，我们将在小鼠中复制与人类男性不育相关的高置信度遗传变异。这样做将允许指定明确的基因型-表型相关性，并为临床医生和患者制定高置信度的建议。它还将提供一种手段来定义作用机制和未来促生育治疗的工具。