The Ghost in the Machine: understanding how haemostasis is regulated by allosteric disulphide bonds

基因编码蛋白质，蛋白质是生命的机械。所有的生命形式都会制造含有半胱氨酸氨基酸对之间的键的蛋白质，这种氨基酸对被称为二硫键。霍格教授发现了一种二硫键，即变构二硫化物，它通过精确地断裂或形成来控制蛋白质的工作。他的研究目标是确定变构二硫化物是如何控制止血的。止血出问题会导致心脏病发作和中风。

Genes encode proteins, which are the machinery of life. All life forms make proteins that contain bonds between pairs of cysteine amino acids called disulphide bonds. Prof Hogg has discovered a type of disulphide bond, the allosteric disulphide, which controls how proteins work by breaking or forming in a precise way. His research aim is to define how haemostasis is controlled by allosteric disulphides. Haemostasis gone wrong leads to heart attack and stroke.