The Phylodynamics of Human Enteroviruses: Informing Vaccine Effectiveness and Outbreak Preparedness

EV-A71等肠道病毒的频率正在增加，在澳大利亚，已导致患有严重脑炎的儿童住院治疗。然而，它们的进化和流行病学的主要方面尚不清楚。我们将通过揭示哪些肠道病毒在该地区流行、是否在特定地区出现、一些是否通常与严重脑炎有关，以及一些是否构成更大的流行威胁，来提供对这些重要病原体的新见解。

Enteroviruses such as EV-A71 are increasing in frequency and in Australia have resulted in the hospitalization of children with severe encephalitis. However, major aspects of their evolution and epidemiology are unknown. We will provide new insights on these important pathogens by revealing which enteroviruses are circulating in the region and whether they arise in specific localities, whether some are commonly associated with severe encephalitis, and whether some pose a greater epidemic threat.