Apo2L/TRAIL killing of tumour cells and the role of Inhibitor of Apoptosis proteins

黑色素瘤和神经胶质瘤是对当前治疗反应较差的肿瘤类型。目前的治疗方法不仅有时无效，而且令人不快，可能会造成同侧损伤。我们将测试两种新的靶向抗癌治疗方法，到目前为止，这些方法在小动物模型中似乎有轻微的副作用，对这些难以治疗的肿瘤类型进行测试，看看它们是否以及如何杀死它们。我们还想知道这些独立的治疗方法是否可以协同工作，更有效地杀死肿瘤。虽然我们不会亲自在临床环境中测试这些药物，但这些药物或类似药物目前正在临床前和临床试验中。这意味着了解这些药物的功能是至关重要的，可能会导致更好的临床试验，并可能更快地接受患者使用这些药物。

Melanomas and Gliomas are tumour types that respond poorly to current treatments. Current treatments are not only sometimes ineffective, but also unpleasant and may cause co-lateral damage. We will test 2 new targetted anti-cancer treatments, that so far appear to have minor side effects in small animal models, on these difficult to treat tumour types to see if and how they kill them. We also want to know whether these independent treatments can work together to kill tumours more effectively. Although we will not personally test these drugs in clinical settings, these drugs or similar are currently in preclinical and clinical trials. This means that understanding how these drugs function is of paramount importance and may result in better clinical trials and possibly more rapid acceptance of the use of these drugs in patients.