The molecular basis for manganese uptake by pathogenic bacteria.

细菌耐药性对人类健康的威胁越来越大。在这个时候，有一个迫切的，根本的需要，新的抗菌策略的发展。细菌感染涉及病原体和人类宿主之间对生命必需营养素的持续拔河，包括微量金属营养素如Mn。该项目旨在了解致病菌吸收Mn的机制，作为新型抗菌设计的目标。

Bacterial antimicrobial resistance is an increasing threat to human health. At this point in time, there is an urgent, fundamental need for the development of new antimicrobial strategies. Bacterial infection involves a constant tug-of-war between the pathogen and the human host for the essential nutrients of life, including trace metal nutrients such as Mn. This project seeks to understand the machinery for Mn uptake by pathogenic bacteria as a target for novel antibacterial design.