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The nature and significance of clonal evolution in human melanoma

The nature and significance of clonal evolution in human melanoma
人类黑色素瘤克隆进化的性质和意义
批准号:
nhmrc : 1008790
负责人:
Prof Mark Shackleton
金额:
$44.37万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

项目摘要

项目成果

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中文摘要
翻译
癌症可以通过发展有利于癌细胞生长、存活和扩散的遗传变化在患者体内进展。然而,人类癌症中发生遗传变化的速度尚不清楚。该项目将通过使用从单细胞生长肿瘤并比较它们之间的遗传差异的新方法来确定人类黑色素瘤中遗传变化的程度和生物学意义。
英文摘要
Cancers can progress in patients by developing genetic changes that favor the growth, survival and spread of cancer cells. However, the rate at which genetic changes occur in human cancer is not known. This project will determine the degree and biological significance of genetic change in human melanoma by using a novel method of growing tumors from single cells and comparing genetic differences between them.
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Deciphering mechanisms of disease evolution in melanoma
  • 批准号:
    nhmrc : GNT1080253
  • 项目类别:
    Project Grants
  • 资助金额:
    $81.15万
  • 财政年份:
    2015
  • 负责人:
    Prof Mark Shackleton
  • 依托单位:
Deciphering mechanisms of disease evolution in melanoma
  • 批准号:
    nhmrc : 1080253
  • 项目类别:
    Project Grants
  • 资助金额:
    $56.35万
  • 财政年份:
    2015
  • 负责人:
    Prof Mark Shackleton
  • 依托单位:
MDM4: a new target for melanoma treatment
  • 批准号:
    nhmrc : 1058897
  • 项目类别:
    Project Grants
  • 资助金额:
    $44.38万
  • 财政年份:
    2014
  • 负责人:
    Prof Mark Shackleton
  • 依托单位:
The significance of cellular heterogeneity in melanoma
  • 批准号:
    nhmrc : 628735
  • 项目类别:
    Career Development Fellowships
  • 资助金额:
    $6.4万
  • 财政年份:
    2010
  • 负责人:
    Prof Mark Shackleton
  • 依托单位:
海外基金