The precise steps in dendritic cell development
The precise steps in dendritic cell development
批准号:
nhmrc : GNT1100033
负责人:
Dr Andrey Kan
金额:
$33.1万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
树突状细胞(DC)是机体的哨兵,具有三种专门的亚型。它们监测感染和癌症,然后激活免疫T细胞来清除它们。有趣的是,它们都可以从单个细胞产生,但确切的步骤尚不清楚。通过拍摄这个过程并分析电影,我们希望绘制出导致他们一代的“家谱”。这些知识将为如何增加或减少它们在医学应用中的数量提供重要线索。
英文摘要
Dendritic cells (DCs) are the body’s sentinels, with three specialized subtypes. They monitor for infections and cancer and then activate immune T cells to clear it. Interestingly, they can all arise from a single cell, but the precise steps are unknown. By literally filming this process and analyzing the movie, we hope to draw the ‘family trees’ that lead to their generation. This knowledge will offer crucial clues as to how to boost or reduce their numbers for medical applications.
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会议论文
The molecular and cellular trajectories of clonal dendritic cell development
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批准号:nhmrc : GNT1145184
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项目类别:Project Grants
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资助金额:$82.67万
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财政年份:2018
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负责人:Dr Andrey Kan
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依托单位:
IL21, B-cell Proliferation and the Mechanism of Memory Formation
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批准号:nhmrc : GNT1146617
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项目类别:Project Grants
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资助金额:$96.83万
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财政年份:2018
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负责人:Dr Andrey Kan
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依托单位:
海外基金