Imaging the generation and recall of protective antiviral immune responses in vivo

我们对感染性疾病的细胞免疫反应的体内动力学的理解很差。该项目将利用先进的活体成像结合新的工具来解剖参与局部病毒感染的T细胞反应的产生和回忆的细胞事件，并结合淋巴器官基质的详细功能分析。这些基本信息将有助于开发新一代疫苗和疗法，以预防组织特异性传染病，癌症和自身免疫性疾病。

Our understanding of the in vivo dynamics of cellular immune responses to infectious diseases is poor. This project will utilise advanced intravital imaging combined with novel tools to dissect the cellular events involved in the generation and recall of T cell responses to localised virus infection, combined with a detailed functional analysis of the lymphoid organ stroma. Such fundamental information will contribute to the development of new generation vaccines and therapies to protect against tissue-specific infectious diseases, cancers and autoimmune diseases.