Australia Fellowship - Grant ID:631668

通过澳大利亚联谊会，马蒂克教授将带领一组研究人员探索这一论点的科学和应用层面，即人类基因组不是主要由进化碎片组成，而是编码了一个非常复杂的信息套件，主要通过RNA进行交易。这项工作将包括检查非编码RNA在不同组织和细胞以及不同疾病状态下的表达模式，探索与DNA和各种蛋白质相关的RNA的位置和动态，以确定这些RNA如何影响基因表达，对这些RNA的选定子集进行有针对性的功能分析，以确定它们作为对其他RNA的原则性证明的生物学功能，探索RNA编辑蛋白的作用，以及测试RNA指导的DNA重新编码可能支持记忆形成的假设。如果正确，该项目的结果将改变我们对人类生物学、发育和大脑功能的理解，并为未来对人类健康和疾病的研究创建一个开明的框架。

Through the Australia Fellowship Prof Mattick will lead a team of researchers to explore the scientific and applied dimensions of the thesis that the human genome is not largely comprised of evolutionary debris, but encodes an extraordinarily sophisticated information suite that is largely transacted by RNA. The work will include examination of the expression patterns on noncoding RNAs in different tissues and cells and different disease states, exploration of the location and dynamics of RNAs associated with DNA and various proteins to determine how these RNAs influence gene expression, targeted functional analyses of selected subsets of these RNAs to determine their biological function as proof-of-principle for others, exploration of the roles of RNA editing proteins, and testing of the hypothesis that RNA-directed DNA recoding might underpin memory formation. If correct, the results of the project will transform our understanding of human biology, development, and brain function, and create an enlightened framework for future research into human health and disease.