Dual-station glove box for the manipulation of sensitive synthetic intermediates

对建筑复杂目标的综合研究往往会导致创新和创造性的联系中断。因此，我们的研究使用天然产物作为开发新合成方法的灵感。 这种新的方法包括使用有机金属试剂开发新的键结构技术，对映体选择性合成的积木全合成，和开发和评估的级联过程的快速，非对映体选择性合成的密集功能化的分子。 我的研究计划的所有目标的核心是使用高活性的有机化合物和金属络合物，无论它们是不对称催化剂，敏感的有机中间体，还是级联反应的钯催化剂。 大多数这些化合物和复合物都是空气和水分敏感的，必须在惰性气氛下使用严格干燥的溶剂进行处理。 我们目前没有能力充分储存和操纵我们日常使用的高活性复合物。 因此，具有溶剂净化系统的手套箱对于本研究计划的各个方面都至关重要。

Synthetic investigations into architecturally complex targets often lead to innovative and creative bond disconnections. Our research, therefore, uses natural products as inspiration for the development of new synthetic methodology.  This new methodology encompasses the use of organometallic reagents for the development of new bond construction techniques, the enantioselective synthesis of building blocks for total synthesis, and the development and evaluation of cascade processes for the rapid, diastereoselective synthesis of densely functionalized molecules.         Central to all of the goals of my research program is the use of highly reactive organic compounds and metal complexes, whether they are asymmetric catalysts, sensitive organic intermediates, or palladium catalysts for cascade reactions.  Most of these compounds and complexes are both air- and moisture-sensitive, and must be handled under inert atmosphere using rigorously dried solvents.  We currently do not have the capability to adequately store and manipulate the highly reactive complexes we use daily.  A glove box with a solvent purification system is therefore essential for every aspect of this research program.