Biochemical and molecular dissection of the mechanisms controlling ribosome biogenesis by the PI3K/AKT/mTOR/MYC network

核糖体的合成和功能对于正常的细胞生长和分裂至关重要，因此该过程受到精细的调节。相反，失调的细胞生长可能导致癌症。我们已经确定了AKT和SGK激酶家族在控制这一过程中的新作用。该提案旨在建立这些酶控制核糖体合成的机制，以更好地了解生长控制，并为靶向生长驱动型癌症中的这些途径提供见解。

Ribosome synthesis and function are critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely, de-regulated cell growth can lead to cancer. We have identified new roles for the AKT and SGK families of kinases in controlling this process. This proposal aims to establish the mechanisms by which these enzymes control ribosome synthesis to better understand growth control and to provide insight for targeting these pathways in growth driven cancers.