Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort

阿尔茨海默病(AD)是痴呆症最常见的形式，但尸检是唯一确定的诊断。目前的建议旨在调查由于遗传突变而患上阿尔茨海默氏症的个人相对于非突变携带者的家庭成员的生化特征的变化，以确定与AD相关的血液变化，这可能有助于开发一种诊断该疾病的血液测试。

Alzheimer’s disease (AD) is the most common form of dementia and yet a postmortem examination serves as the only definitive diagnosis. The current proposal seeks to investigate alterations in biochemical profiles of individuals who will develop Alzheimer’s disease due to an inherited mutation, against family members who are non-carriers of the mutation, to identify AD related blood changes which can contribute towards the development of a diagnostic blood test for the disease.