Bone marrow macrophages: “Resident Evil” in the establishment and progression of multiple myeloma

多发性骨髓瘤(MM)是一种在骨髓(BM)内发展的癌症。到目前为止，骨髓基质中的哪些细胞是支持MM生长所必需的仍不清楚。我们的初步数据表明，表达CD169和CX3CR1的骨髓驻留巨噬细胞对MM的生长是必不可少的。使用创新和优雅的多发性骨髓瘤动物模型，我们将确定这些巨噬细胞在多发性骨髓瘤生长中的作用，并确定巨噬细胞靶向治疗是否可以延缓复发疾病背景下多发性骨髓瘤的生长。

Multiple myeloma (MM) is a cancer that develops within the bone marrow (BM). To date, which cells of the BM stroma are required for the support of MM growth remains unknown. Our preliminary data suggest BM resident macrophages, expressing CD169 and CX3CR1, are essential for MM growth. Using innovative and elegant animal models of MM, we will define the role of these macrophages in MM growth and determine if macrophage-targeted therapies can delay MM growth in the relapsed disease setting.