CD4 T cell function and HIV-1 infection

本申请建议详细研究HIV感染的主要靶细胞，即CCR5+CD4T淋巴细胞。在大流行30年后，对这些细胞的基本知识仍然缺乏，例如在体内的位置、与其他淋巴细胞的分化以及生存。这些属性决定了他们是否会感染艾滋病毒，是否可以通过疫苗或CCR5阻断药物来预防，以及他们的长期生存是否导致无法根除艾滋病毒。

This application proposes to study in detail the main target cell for HIV infection, namely CCR5+ CD4 T lymphocytes. After 30 years of the pandemic, fundamental knowledge of these cells, such as locations in the body, differentiation from other lymphocytes, and survival, is still lacking. These attributes determine whether or not they will be infected by HIV, whether this can be prevented by vaccines or CCR5 blocking drugs, and whether their long-term survival results in an inability to eradicate HIV.