Cell swelling and EEG ripples: components in the transformation of normal brain activity into seizure

癫痫是一种高度衰弱的疾病，发作往往控制不佳。使用一种新的多学科方法，本建议的目的是定义在癫痫发作开始和扩散期间细胞肿胀和神经细胞脑活动的参与。本研究提出了一种新的癫痫诱发机制，为癫痫研究提供了一个新的范式转移，并为癫痫干预提供了新的药理学靶点。

Epilepsy is a highly debilitating conditioned and seizures are often poorly controlled. Using a novel multidisciplinary approach, the aim of this proposal is to define the participation of cell swelling and nerve cell brain activity during the start and spread of seizures. This research introduces a novel seizure induction mechanism and provides a paradigm shift in focus for epilepsy research, as well as suggests new pharmacologic targets for seizure-intervention.