Cellular pathogenesis of neurodegenerative disorders

阿尔茨海默病是老年人最常见的神经退行性疾病，与β肽的毒性有关。朊病毒疾病（如人类CJD）是由朊病毒蛋白错误折叠引起的传染性神经退行性疾病。本提案旨在利用新的细胞和动物研究，将这些疾病的相似特征结合起来，以发展更好的诊断和更深入地了解这些疾病的分子基础，以期开发介入治疗方法。

Alzheimer's disease is the most common neurodegenerative disease of the ageing population and is associated with toxicity of the Abeta peptide. Prion diseases (eg CJD in humans) are infectious neurodegenerative disorders caused by misfolding of the prion protein. This proposal aims to bring together similar features of these diseases using novel cell and animal based studies to develop better diagnostics and greater understanding of the molecular basis of these disorders with a view to developing interventional therapies.