Central Nervous System Dendritic Cells – Guilty or Not Guilty?

尽管中枢神经系统在结构和功能上都是独一无二的，但它必须能够产生保护性免疫反应。然而，局部和中央免疫调节过程的崩溃可能会导致临床上的炎症性疾病，如葡萄膜炎和多发性硬化症。该项目将研究树突状细胞在影响眼睛和大脑的自身免疫性疾病模型中的作用。这些数据将极大地帮助我们设计新的免疫疗法来治疗这些致盲和致残的疾病。

The central nervous system although structurally and functionally unique, must be able to mount protective immunological responses. However, breakdown in local and central immunoregulatory processes can lead to clinically disabling inflammatory conditions such as uveitis and multiple sclerosis. This project will investigate the role of Dendritic cells in models of autoimmune diseases affecting the eye and brain. The data will greatly aid our ability to design new immunotherapies to treat these blinding and crippling diseases.