Ionic liquids supported synthesis

相对于普通的有机溶剂，离子液体具有一些有趣的性质：高的热稳定性和化学稳定性，几乎没有可测量的蒸汽压，不燃烧，减少摩擦，抗磨性能和高负载能力。 许多化学反应，包括一些酶反应，可以在离子液体中进行。 室温离子液体也已被探索为用于化学萃取和其他工业过程的环境友好介质。 在许多情况下，离子液体可以容易地回收。 离子液体的一个吸引人的特征是它们的溶解度可以容易地调节，使得它们可以根据阳离子和阴离子的选择与有机以及水性介质相分离。也可以调节底物溶解度。这表明，使用这些低分子量的离子液体作为有机合成的可溶性载体的可能性。 可以实现“离子液体相”、有机相和水相之间的相分离以用于产物分离和纯化。 在这项拟议的研究中，我们打算展示离子液体支持合成（ILSS）用于合成小分子、寡肽、低聚糖、寡核苷酸和糖肽的一般策略。 此外，我们将展示使用离子液体负载的硫化合物作为减少挥发性有机硫化合物气味的一种方式。 离子液体负载有机催化剂的探索也将进行。

Relative to common organic solvents, ionic liquids have some intriguing properties: high thermal and chemical stability, nearly no measurable vapor pressure, non-flammability, friction reduction, anti-wear performance and high loading capacity.  Numerous chemical reactions, including some enzymic reactions, can be carried out in ionic liquids.  Room temperature ionic liquids have also been explored as environmentally benign media for chemical extractions and other industrial processes.  In many cases, the ionic liquids can be recycled easily.  An attractive feature of ionic liquids is that their solubilities can be tuned readily so that they can phase separate from organic as well as aqueous media depending on the choice of cations and anions. Substrate solubility can also be tuned. This suggests the possibility of using these low molecular weight ionic liquids as soluble supports for organic synthesis.  Phase separation between the "ionic liquid phase", the organic phase, and the aqueous phase can be achieved for product separation and purification.  In this proposed research, we intend to demonstrate the general strategy of ionic liquid support synthesis (ILSS) for the synthesis of small molecules, oligopeptides, oligosaccharides, oligonucleotides, and glycopeptides.  In addition, we will demonstrate the use ionic liquid supported sulfur compounds as a way to reduce the odor of volatile organosulfur compounds.  The exploration of ionic liquid supported organocatalysts will also be carried out.