Surface-coated metal nanoparticles with carbohydrate polymers as

表面包覆的金属纳米颗粒作为治疗递送剂正在彻底改变生物医学技术。目前，有几种方法正在开发用于细胞特异性靶向纳米颗粒的系统给药，但这些颗粒在细胞/体内的命运往往不能很好地控制。我们的研究重点是开发先进的多功能纳米材料，克服组织和细胞内的运输限制。我们的目标是制备具有明确定义的碳水化合物聚合物的表面涂层金属纳米颗粒，以提高溶解度和稳定性（在复杂混合物中聚集较少），增强表面吸附的抵抗力，延长血液循环时间，减少蛋白质和细胞粘附，降低毒性和减少组织中的异物反应。

Surface coated metal nanoparticles as therapeutic delivery agents are revolutionizing biomedical technologies. Currently there are several approaches being developed for cell-specific targeting of nanoparticles from systemic administration, but the fate of these particles inside the cell/body is often not well controlled. Our research focuses on developing advanced multifunctional nano-based materials that overcome transport limitations in tissues and within cells. Our goal is to prepare surface coated metal nanoparticles with well-defined carbohydrate polymers for improved solubility and stability (less aggregation in complex mixture), more resistance to surface adsorption, prolonged circulation time in bloodstream, reduced protein and cell adherence, reduced toxicity and reduced foreign body response in tissues.