Characterization of casein phosphopeptide amorphous calcium fluoride phosphate as a remineralization system

龋齿（蛀牙）仍然是澳大利亚的一个主要公共卫生问题，每年造成的经济负担超过10亿美元。该项目的总体目标是开发一种新型再矿化剂（酪蛋白磷酸肽稳定的无定形氟化钙磷酸盐），用于早期蛀牙病变（白斑病变）的再矿化。该项目将包括测试新型再矿化系统在体外和原位再矿化（修复）白斑病变的能力。该项目还涉及使用核磁共振波谱和其他技术详细描述再矿化系统组分的分子相互作用。预计该项目将导致开发出一种具有本质上优越性能的系统，用于白斑病变的非侵入性治疗（逆转），并可能最终导致开发出一种治疗和预防蛀牙的新型系统。

Dental caries (tooth decay) remains a major public health problem in Australia with an economic burden in excess of $1 billion p.a. The overall aim of this project is the development of a novel remineralizing agent (casein phosphopeptide stabilized amorphous calcium fluoride phosphate) for the remineralization of early tooth decay lesions (white spot lesions). The project will involve the testing of the ability of the novel remineralization system to remineralize (repair) white spot lesions in vitro and in situ. The project also involves the detailed characterization of the molecular interactions of the components of the remineralizing system using NMR spectroscopy and other techniques. It is anticipated that this project will result in the development of a system with substantialy superior properties for the non-invasive treatment (reversal) of white spot lesions and may ultimately lead to the development of a novel system for the treatment and prevention of tooth decay.