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Regulation of astrocytic gliosis and axonal regeneration in EAE by EphA4

Regulation of astrocytic gliosis and axonal regeneration in EAE by EphA4
EphA4 对 EAE 中星形胶质细胞增生和轴突再生的调节
批准号:
nhmrc : 566513
负责人:
A/Pr Ann Turnley
金额:
$35.5万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31

项目摘要

项目成果

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中文摘要
翻译
多发性硬化症(MS)是一种使人衰弱的疾病,目前还没有有效的治疗方法。除了失去被称为髓鞘的保护性绝缘鞘外,神经细胞也会受损,并形成疤痕。如果这是可以预防的,那么多发性硬化症可能会得到更好的治疗。利用一种名为EAE的多发性硬化症模型,将检验一种名为EphA4的分子的作用,以确定其诱导神经丢失和疤痕形成的能力,并确定阻断它是否会促进修复,从而导致多发性硬化症的治疗。
英文摘要
Multiple Sclerosis (MS) is a debilitating disease with currently no effective cure. Apart from losing the protective insulating sheath called myelin, nerve cells are damaged and a scar forms. If this could be prevented then MS may be better treated. Using a model of MS called EAE, the role of a molecule, EphA4, will be examined for its ability to induce nerve loss and scar formation and to determine whether blocking it will promote repair, leading to a therapy for MS.
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