Regulation of autoimmunity by non-apoptotic caspases

过度的细胞死亡会导致慢性炎症和自身免疫。细胞可以通过不同的机制死亡，包括引起炎症的坏死性凋亡和不引起炎症的凋亡。最近的研究表明，半胱天冬酶，细胞凋亡途径的一个组成部分，加速细胞死亡，也阻止免疫激活死亡细胞。我将研究半胱天冬酶是否有助于自身免疫性疾病，以及半胱天冬酶是否可以抑制坏死性细胞死亡期间发生的炎症。

Excessive cell death can lead to chronic inflammation and autoimmunity. Cells can die by different mechanisms including necroptosis which causes inflammation, and apoptosis which does not. Recent studies show that caspases, a component of the apoptosis pathway which accelerate cell death, also prevent immune activation by dying cells. I will investigate whether caspases contribute to autoimmune disease and whether caspases can dampen the inflammation that occurs during necroptotic cell death.