Oxygen therapeutics: Designs and tests

氧气疗法的目的是提高对有需要的病人的氧气供应，如失血或疾病。这种产品有许多有价值的应用，包括能够作为传统输血的无菌长期替代品，特别是在血库不容易到达的地方。氧治疗的一种常见途径是基于化学改变血红蛋白，给予基于血红蛋白的氧载体（HBOC）。对hboc的研究表明，它们可能会导致血压升高。一个可能的原因是它与一氧化氮的相互作用，一氧化氮负责保持血管放松。另一种可能是对HBOC氧气突然增加的反应。这项研究将产生血红蛋白的特征性修饰，以获得确定的HBOC分子。每个都将用于测试与一氧化氮和氧气释放的相互作用。我们将在动物模型中测试其效果，以确定血管活性。在进一步的方面，我们将制备能够添加一氧化氮的HBOC材料，有可能降低血压。设计将根据这些信息进行迭代改进。在每个阶段，我们将与用户部门的参与者讨论我们的进展。

Oxygen therapeutics are designed to enhance the availability of oxygen to a patient with a need such as in blood loss or disease. Such products have many valuable applications, including the ability to serve as a sterile, long-term alternative to a conventional transfusion, especially where blood banks are not easily reached. A common route to an oxygen therapeutic is based on chemically altering hemoglobin, to give a hemglobin-based oxygen carrier (HBOC). Work with HBOCs shows that they may cause elevated blood pressure. One likely reason is that interaction with nitric oxide, which is responsible for keeping blood vessels relaxed. Another possibility is a response to a sudden increase in oxygen from the HBOC. The research will produce characteristic modifications in hemoglobin to give defined HBOC molecules. Each will be used to test interaction with nitric oxide and oxygen release. We will test the effects in an animal model designed to determine vasoactivity. In a further aspect, we will prepare HBOC materials that are capable of adding nitric oxide, potentially reducing blood pressure. Designs will be iteratively improved with this information. At each stage we will discuss our progress with user sector participants.