Inorganometallic chemistry: transformations of phosphorus ligands in transition metal complexes

磷的化学性质在许多不同的领域起着重要的作用。在许多工业应用中，磷化合物的一些用途是肥料、杀虫剂、阻燃剂和洗涤剂。在许多其他生物功能中，磷化合物也是细胞能量循环的重要组成部分。这个建议涉及到发展合成磷化合物的新技术。有机化学中许多重要的合成技术都涉及过渡金属配合物。由于磷的化学性质经常与碳的化学性质相似，涉及金属配合物的技术也可能对形成磷化合物有用。我们将开发利用过渡金属配合物合成有机磷化合物的新技术。金属配合物有助于在不寻常的环境中稳定磷，使其具有特别的活性，从而有助于合成。我们感兴趣的是有金属磷单键的磷脂配合物，有金属磷双键的磷脂，和有金属磷三键的磷化物。我们的磷化合物的一个应用是合成膦基催化剂的配体。磷化氢催化剂在许多工业中都很重要，包括制药工业。我们的过渡金属磷化学的其他潜在应用包括用于制造含磷聚合物的构建块的形成，以及新的含磷生物活性分子的形成。

The chemistry of phosphorus plays an important role in many different fields. A few of the many industrial applications of phosphorus compounds are fertilizers, pesticides, fire retardants, and detergents. Phosphorus compounds also form a critical part of the energy cycle of cells, among many other biological functions. This proposal involves the development of new techniques for synthesizing compounds of phosphorus. Many important synthetic techniques in organic chemistry involve transition metal complexes. Since the chemistry of phosphorus often resembles that of carbon, techniques involving metal complexes may also be useful for forming phosphorus compounds. We will be developing new techniques for the synthesis of organophosphorus compounds, using transition metal complexes. Metal complexes are useful for stabilizing phosphorus in unusual environments that make it particularly reactive, and thus useful for synthesis. We are interested in phosphido complexes, which have metal phosphorus single bonds, phosphinidenes, which have metal-phosphorus double bonds, and phosphides, which have metal-phosphorus triple bonds. One application of our phosphorus compounds is synthesis of ligands for phosphine-based catalysts. Phosphine catalysts are important in many industries, including the pharmaceutical industry. Other potential applications of our transition-metal phosphorus chemistry include the formation of the building blocks used to make phosphorus-containing polymers, and the formation of new biologically active molecules containing phosphorus.