Regulation of neural progenitor cell self-renewal by the RNA-binding protein ZFP36L1 during development and disease

神经干细胞的及时分化在发育过程中至关重要，成人神经干细胞的无限制增殖可导致致命的脑癌，如胶质瘤。目前，我们对这些过程中调节神经干细胞行为的关键分子的理解仍然有限。在这个提议中，我们将研究神经干细胞生物学的分子决定因素，包括发育中的大脑和胶质瘤。

The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.