Self assembling and targeting smart biomaterials for Dengue virus diagnostics and therapeutics

这项拨款与登革热病毒感染的检测、预防和治疗有关。该病毒是一种蚊子传播的病毒，在全世界感染了1亿人。在其严重的形式，它可以导致5%的人死亡。这种病毒的两种毒株现在也在北美流行。这项研究的目标是与一家加拿大公司（Cangene Inc，温尼伯和多伦多）合作，开发用于检测和治疗该疾病的智能生物材料。更具体地说，将开发一种简单的基于拭子或试纸的免疫测定法，用于感染个体的非侵入性检测。还将测试类似的抗体用于预防和治疗组织培养和登革热病毒感染的小鼠模型中的感染。

This grant relates to the detection, prevention and treatment of Dengue virus infection. The virus is a mosquito borne virus that infects 100 million individuals worldwide. In its severe form it can cause death in 5% of the individuals. Two strains of this virus is now also prevalent in North America. The objectives of this research in collaboration with a Canadian company (Cangene Inc, Winnipeg and Toronto) is to develop smart biomaterials for detection and treatment of the disease. More specifically, a simple swab or dipstick based immunoassay will be developed for non-invasive detection of infected individuals. Similar antibodies are also to be tested for prevention and treatment of infection in tissue culture and mouse models of dengue viral infection.